Hereditary fructose intolerance is a disorder in which a person lacks the protein needed to break down fructose. Fructose is a fruit sugar that naturally occurs in the body. Man-made fructose is used as a sweetener in many foods, including baby food and drinks.
Causes
This condition occurs when the body is missing an enzyme called aldolase B. This substance is needed to break down fructose.
If a person without this substance eats fructose or sucrose (cane or beet sugar, table sugar), complicated chemical changes occur in the body. The body cannot change its stored form of sugar (glycogen) into glucose. As a result, blood sugar falls and dangerous substances build up in the liver.
Hereditary fructose intolerance is inherited, which means it can be passed down through families. If both parents carry a nonworking copy of the aldolase B gene, each of their children has a 25% (1 in 4) chance of being affected.
Symptoms
Symptoms can be seen after a baby starts eating food or formula.
The early symptoms of fructose intolerance are similar to those of galactosemia (inability to use the sugar galactose). Later symptoms relate more to liver disease.
Symptoms may include:
Convulsions
Excessive sleepiness
Irritability
Yellow skin or whites of the eyes (jaundice)
Poor feeding and growth as a baby, failure to thrive
Problems after eating fruits and other foods that contain fructose or sucrose
Vomiting
Exams and Tests
Physical examination may show: Enlarged liver and spleen
Jaundice
Tests that confirm the diagnosis include:
Blood clotting tests
Blood sugar test
Enzyme studies
Genetic testing
Kidney function tests
Liver function tests
Liver biopsy
Uric acid blood test
Urinalysis
Blood sugar will be low, especially after receiving fructose or sucrose. Uric acid levels will be high.
Treatment
Removing fructose and sucrose from the diet is an effective treatment for most people. Complications may be treated. For example, some people can take a medicine to lower the level of uric acid in their blood and decrease their risk for gout.
Outlook (Prognosis)
Hereditary fructose intolerance may be mild or severe.
Avoiding fructose and sucrose helps most children with this condition. The prognosis is good in most cases.
A few children with a severe form of the disease will develop severe liver disease. Even removing fructose and sucrose from the diet may not prevent severe liver disease in these children.
How well a person does depends on: How soon the diagnosis is made
How soon fructose and sucrose can be removed from the diet
How well the enzyme works in the body
Possible Complications
These complications may occur: Avoidance of fructose-containing foods due to their effects
Bleeding
Gout
Illness from eating foods containing fructose or sucrose
Low blood sugar (hypoglycemia)
Seizures
Death
When to Contact a Medical Professional
Call your health care provider if your child develops symptoms of this condition after feeding starts. If your child has this condition, experts recommend seeing a doctor who specializes in biochemical genetics or metabolism.
Prevention
Couples with a family history of fructose intolerance who wish to have a baby may consider genetic counseling.
Most of the damaging effects of the disease can be prevented by decreasing fructose and sucrose intake.
Alternative Names
Fructosemia
Fructose intolerance
Fructose aldolase B-deficiency
Fructose-1, 6-bisphosphate aldolase deficiency
References
Bonnardeaux A, Bichet DG. Inherited disorders of the renal tubule. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector’s The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 44.
Kishnani PS, Chen Y-T. Defects in metabolism of carbohydrates. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 105.
Mojica A, Weinstock RS. Carbohydrates. In: McPherson RA, Pincus MR, eds. Henry’s Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2022:chap 17.
Scheinman SJ. Genetically based kidney transport disorders. In: Gilbert SJ, Weiner DE, eds. National Kidney Foundation’s Primer on Kidney Disease. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 38.
Source
MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US) Available from:: https://medlineplus.gov/ency/article/000359.htm
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