inflammation

Gout ‘more than doubles’ risk of kidney failure

Largest ever study on subject uses data from more than 620,000 patients in UK health system

Date: August 28, 2019
Source:University of Limerick
Summary: Patients with gout are at increased risk of chronic kidney disease and kidney failure, according to new research.

Patients with gout are at increased risk of chronic kidney disease and kidney failure, according to new University of Limerick (UL), Ireland led research.

In one of the largest and most detailed studies ever conducted, patients recruited in general practice with a diagnosis of gout were more than twice as likely to develop kidney failure than those without, according to the study led by researchers at University of Limerick’s (UL) Graduate Entry Medical School (GEMS).

Wearable sweat sensor detects gout-causing compounds

Date:November 25, 2019

Source: California Institute of Technology

Summary: Scientists have developed an easier way to mass-produce highly sensitive sweat sensors that can detect a variety of low-concentration compounds related to health conditions.

There are numerous things to dislike about going to the doctor: Paying a copay, sitting in the waiting room, out-of-date magazines, sick people coughing without covering their mouths. For many, though, the worst thing about a doctor’s visit is getting stuck with a needle. Blood tests are a tried-and-true way of evaluating what is going on with your body, but the discomfort is unavoidable. Or maybe not, say Caltech scientists.

Gout Questions and Answers

Let us better help you better understand this condition – despite the tons of misinformation that circulates on the internet.

Why are blood test results misleading when it comes to a Gout diagnosis?

Blood tests can reveal the concentration of uric acid in your system. However, while you are under an attack your blood could potentially read quite normal. Over 60% of patients presenting with acute gouty arthritis symptoms have uric acid levels of <8mg/dl. Measuring serum uric acid levels while under an attack may not be too helpful in a diagnostic sense. Why? The crystals relentlessly jabbing at your joints are NOT in a soluble form at that time.

Gobble, Gobble- Important tips regarding Gout and Holiday Meals

It was Thanksgiving of 2014 and our family had just concluded another successful gathering full of feasting and festivities. I recall feeling a bit stressed about all the food I had just consumed; food I knew I could, and likely would, pay for later. When you have Gout that dreaded scenario is likely always weighing on you in the back of your mind. WHAT did I just do to myself?

Is there any chance I could dodge a bullet this time?

What can I possibly do to get ahead of this game?

Maybe if just consume a ton of water, and water only, can I avoid the inevitable?

Was that turkey and gravy, and pie, and, and, and….all worth it?

As Gout sufferers we are all fully aware of the risks involved and sometimes we choose to face those risks head on, despite the potential outcome. I remember wondering then if there were measures to take ahead of time to avoid the worry of a splurge here and there. I was young and dumb, and rather clueless about the sheer number of things I did and consumed on a daily basis that kept adding to my demise. Understanding the necessity of balance was never my strong suit.

…..Fast forward to the middle of the night, post thankful feasting, and I am awakened by a pain in my ankle that I knew all too well; the kind of pain worthy of wishing to lose a limb rather than continue the suffering. Said ankle was red hot, swollen and throbbing in pain. Agony was an understatement and black Friday took on a whole new meaning. There would be no shopping, no leftover turkey stuffing sandwiches, nothing resembling anything remotely close to my ability to leave that bed.

I.WAS.MISERABLE. WHY had I done this to myself, again?? I knew better. I began swallowing Colchicine like candy. Que the digestive disaster in the making. Now, I’m sick as a dog AND in pure agony. Ice, heat, water, Ibuprofen, repeat.

Sound familiar?

That attack was one of the absolute worst to date. It continued to move around to different areas of my body and was categorically relentless. I vowed from that day forward that I was going to avoid ever suffering like that again. A wise man told me that I needed to start looking at this Gout puzzle with more clarity and understanding. He told me that we tend to be very narrow-minded in our approach and limited in thinking that one meal could cause an attack when food purines are such a miniscule piece of this puzzle. What was I doing each and every day to contribute to my “glass of uric acid” until that one meal causes it to spill over into an attack? What could I do to lower that full glass to a point where a splurge wouldn’t push me over that edge?

Some important things I’ve learned:

You may have ‘trigger foods’ that spark an attack. A purine-rich meal may push your ‘already full’ glass over the edge and into an attack. However, be sure to understand things were already brewing and these triggers simply tipped the scale.

SOLUBLE uric acid can be measured in your blood supply. However, the uric acid that has crystallized and is now residing in connective tissue cannot be measured with a blood analysis. These crystals are always there, in a solid form, “melting” when the levels in the blood will allow and adding to the buildup when levels in the blood become too high for the blood to carry. These deposits are what migrate into the joint causing the acute gout attack. When the tissue is full, any food indulgences and lifestyle choices that cause you to produce more uric acid than the blood can hold, will allow for deposits that crystallize between the bone joints. This can make you falsely blame one food for triggering your attack when in all actuality it simply “tipped the already full cup over.”

Cellular regeneration is the only way to achieve Gout control success. Food, water, spices, vitamins, herbs, and therapeutic actions (meditation, exercise, listening to music) can significantly elevate the body’s regenerative process. Together they, and you, can take control of your health and begin repair. While some parts will remain permanently damaged, there are many areas where an overhaul can bring you the quality of life you have been missing.

Why Does Gout Attack at Night?

Why Do Low-Purine Diets Fail?

Important tips regarding Gout and other Inflammatory Conditions

Gout Diet: Are Impossible Burgers/Foods Impossible To Be Good For You?

We seem to have found ourselves at yet another set of crossroads regarding conflicting ideas when it comes to lab-grown foods such as the Impossible Burger. It may be easy to assume ‘plant-based’ diets are healthy, but are they? We know that highly processed foods are unhealthy and unfortunately this new fad of plant-based foods are exactly that, highly processed. Continue reading

Artichoke Powder for Gout and Joint Health

ARTICHOKE POWDER (Globe Artichoke)

A relative of the hepatoprotective Milk Thistle, is popular for its pungent taste which is attributed to phytochemicals found in the green parts of the plants called cynaropicrin and cynarin, sesquiterpene lactones with documented medicinal actions. The phytochemicals in artichoke have been well documented and the leaves rather than the flower have been found to be higher in medicinal value.

Artichokes contain a very high antioxidant content, and in fact, contain two compounds (apigenin 7-rutinoside and narirutin) that are so unique they aren’t found in any other plant.

Traditional uses have included support for sluggish liver, poor digestion and atherosclerosis. Artichokes offer concentrated sources of amino acids and even help to support the natural growth of probiotics for the digestive system.

Continue reading “Artichoke Powder for Gout and Joint Health”

Cell Death, Cellular Toxicity, and Gout

Considering that all disease occurs at the molecular and cellular level, could all disease share common causes and common solutions?

Toxic damage to cells leads to cellular death, and in large numbers can result in tissue and organ damage/failure. Some tissues and organs hold the capacity for self-repair, while others have no ability to regenerate. For example, the liver can repair damaged sections by fibrous replacement, whereas the nervous system tissue has no ability to regenerate itself. Of course, even the liver will have trouble if the damage is severe and/or continues to suffer from abuse.

Continue reading “Cell Death, Cellular Toxicity, and Gout”

What is TAK1 and why is it important to inhibit its potentially destructive pathway?

TAK1 is an enzyme and signaling molecule in humans encoded by the MAP3K7 gene (a mitogen-activated protein). TAK1 regulates cellular death through various pathways. As we have discussed before, programmed cell death is a normal, physiologic process intended to help remove damaged cells. However, unattended cell death is the direct pathway for human disease. TAK1 contains binding proteins that are responsible for cell viability and tissue balance in a variety of organs.

TAK1 is a key molecular component that can readily determine of the fate of our body’s cells. TAK1 has been typically considered pro-survival, however, recent studies have determined that various factors could cause it to induce cell death. Scientifically speaking, studies are exploring the ability to inhibit TAK1 as a therapeutic approach to killing off rogue cancer cells and stopping chronic inflammatory response.

Candidiasis: Yeast overgrowth and Gout

Candida yeast overgrowth in the body can contribute to difficulty with weight loss, inflammation, increased uric acid levels, and a host of other symptoms. In fact, the symptoms of chronic inflammation are extraordinarily similar to those seen in Candida related complex. Digestive problems, allergies, fatigue, and joint pain are no strangers to either condition. We have a bad habit of evaluating conditions separately, when in fact the powerful links between Gout and Candida yeast overgrowth could be addressed collectively.

Harmful substances that enter the bloodstream can cause a host of problems. The byproducts of Candida (acetaldehyde, ammonia, and uric acid) are no exception. Our bodies have a remarkable way of dealing with these invaders that can be both helpful and harmful. Inflammatory response is the key component for your body’s way of healing itself in the presence an injury, an infection, or in this case when dangerous pathogens are invading your system.

Many relate candida yeast solely to women and the vagina infections the yeast can cause. However, yeast can be found in the mouth, intestines, and on the skin. When it begins to grow uncontrollably it can cause an infection known as candidiasis.
We rely on the healthy bacteria levels in our body to keep Candida levels in check. However, in the presence of low “good bacteria” levels (quite common) the immune system becomes compromised and the overproduction of both yeast and Uric Acid can ensue.
Much like uric acid, candida faces similar risk factors that can lead to its overproduction such as:

Antibiotic use
A diet high in sugar and refined carbs
Excessive alcohol intake
Compromised immune system
Prescription medications
Diabetes
Stress

Inflammation and COVID-19 | Gout and Inflammation | Coronovirus | Flu

If you suffer with inflammation (Arthritis, Gout, Diabetes, etc.), are you more susceptible to viruses such as the Flu and COVID-19?

Higher levels of inflammatory markers such as C-reactive protein, ferritin, and D-dimers have been found in the blood of COVID-19 patients. Increased serum levels of several inflammatory cytokines and chemokines have been associated with the severity of the condition, as well as with the deaths involved. The way this virus invades the cells sets off a cytokine (small proteins important in cell signaling) storm, hampering the body’s ability to deal with its destructive path. The strength of the inflammatory response with this virus far exceeds what is typical for other viral infections. We are aware that hyperinflammation has been observed in younger patients without pre-existing conditions, making those with pre-existing inflammation that much more susceptible. You may not think of Gout as a “pre-existing” condition that places you at higher risk, but it most certainly can do just that. Inflammation is still at the root of this painful disease and while your body is already struggling to keep that at bay, your risk factor is naturally higher than others. Additionally, more men seem to be suffering with extreme complications involving COVID-19, even at younger ages, much like we see with the likelihood and severity of Gout in men. Comparatively speaking, premenopausal women seem to be more protected from more severe complications of this virus vs. postmenopausal women — also another common scenario involved with Gout in women. Uncontrolled, chronic inflammation can result in, or be the result of, a dysfunctional immune system. This can make it exceedingly difficult to keep certain pathogens in check and result in triggering an overproduction of immune cells that could flood the lungs. Widespread inflammation can negatively impact all organs of the body. When a virus replicates faster than the immune system can respond the body can quickly become overwhelmed and spiral out of control. This is where updated medical technology is needed to monitor the lungs and other organs. People can click here for info on what is needed to help keep people safe and secure during these terrifying times. While data characterizing the immune and inflammatory status in patients with COVID-19 is in its infancy, it is obvious that inflammation contributes to the disease’s severity and risk of death. Our body’s potent immune response to COVID-19 poses unique risks to the heart, which is likely underestimated by comparison to the lung/respiratory system involvement. Systemic inflammation has been a well-known trigger for cardiovascular events, and this is no exception. As a result, anti-inflammatory treatments, such as Colchicine, are actively being researched as a potential hope for COVID-19 treatment. Researchers are also considering other therapies specific to inhibiting inflammation, such as the sex hormone progesterone. Naturally (pun intended) our company airs on the side of alternative options to prescription anti-inflammatories. We won’t bore you with the gazillion reasons why (links on this page speak for themselves), but we will guide you towards the all-natural options for building your immunity, fighting Gout, fighting inflammation as a whole, and lowering your risk of susceptibility due to your pre-disposition. Taking care of yourself is always important, and even more so considering this pandemic. Mental health is equally as important. Stress, anxiety and depression are very acidic and damaging to the body. Taking care of yourself emotionally needs to remain as much of a priority as doing so physically. The mind is a powerful thing, nurture it.

Tag: inflammation