Tag: fructose

Uric Acid & Gout News: Hereditary Fructose Intolerance




Hereditary fructose intolerance is a disorder in which a person lacks the protein needed to break down fructose. Fructose is a fruit sugar that naturally occurs in the body. Man-made fructose is used as a sweetener in many foods, including baby food and drinks.

Causes



This condition occurs when the body is missing an enzyme called aldolase B. This substance is needed to break down fructose.

If a person without this substance eats fructose or sucrose (cane or beet sugar, table sugar), complicated chemical changes occur in the body. The body cannot change its stored form of sugar (glycogen) into glucose. As a result, blood sugar falls and dangerous substances build up in the liver.

Hereditary fructose intolerance is inherited, which means it can be passed down through families. If both parents carry a nonworking copy of the aldolase B gene, each of their children has a 25% (1 in 4) chance of being affected.

Continue reading “Uric Acid & Gout News: Hereditary Fructose Intolerance”

Uric Acid Metabolism and the Effects of Fructose

Sugar intake has risen dramatically over the last century which seems to correlate closely with the rise in obesity, diabetes, and metabolic syndrome.  Simple sugars include both glucose and fructose.  While glucose is generally utilized by the body for energy production, fructose is known to produce high amounts of harmful substances.  Added sugars to our food sources mostly stem from fructose, and fructose metabolism can cause some pretty significant damage.  Fructose can actually deplete our energy sources, cause death to our cells, stimulate fat making enzymes, and produce excess uric acid.

Studies on rats have shown fructose intake to instigate all markers of metabolic syndrome – increased waistline, obesity, diabetes, hypertension, non-alcoholic fatty liver disease, lipid abnormalities, dementia, cardiovascular disease, and cancer.    These studies have also shown high fructose intake to stimulate free radicals, weaken the arteries, create a fatty liver, and cause kidney damage. Continue reading “Uric Acid Metabolism and the Effects of Fructose”

Fructose and Uric Acid Metabolism

Sugar intake has risen dramatically over the last century which seems to correlate closely with the rise in obesity, diabetes, and metabolic syndrome.  Simple sugars include both glucose and fructose.  While glucose is generally utilized by the body for energy production, fructose is known to produce high amounts of harmful substances.  Added sugars to our food sources mostly stem from fructose, and fructose metabolism can cause some pretty significant damage.  Fructose can actually deplete our energy sources, cause death to our cells, stimulate fat making enzymes, and produce excess uric acid.

Studies on rats have shown fructose intake to instigate all markers of metabolic syndrome – increased waistline, obesity, diabetes, hypertension, non-alcoholic fatty liver disease, lipid abnormalities, dementia, cardiovascular disease, and cancer.    These studies have also shown high fructose intake to stimulate free radicals, weaken the arteries, create a fatty liver, and cause kidney damage.  Continue reading “Fructose and Uric Acid Metabolism”

Gout and Cancer Connection?

Gout and Cancer Connection?

Is there a connection between Gout and Cancer?  Gout is a common inflammatory disease with incidences largely increasing with each passing year and affecting younger and younger age groups  more than ever before.  Acute arthritis and hyperuricemia stems from purine metabolism dysfunction, causing urate crystals to deposit into the tissue leading to kidney stones, soft tissue growths, urate nephropathy and/or arthritis.  Epidemiological studies have been conducted to estimate the potential association between Gout and Cancer risks.  These studies have displayed a preeminent role of Gout in carcinogenesis.

Cellular death and higher turnover rates can bring about hyperuricemia and the formation of tumors (tumorigenesis.)  Even though strong evidence exists to show the connection between high serum uric acid levels and an independent increased risk of cancer, the subject remains disputable. Continue reading “Gout and Cancer Connection?”

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