Occurrence of gout in rheumatoid arthritis: it does happen! A population-based study

Aim

It has been a popular belief that gout does not typically occur in patients with rheumatoid arthritis (RA). Our aim was to assess the occurrence, prevalence, clinical presentation and possible risk factors for gout in patients with RA.

Patients & methods

We retrospectively reviewed a population-based incidence cohort of patients who fulfilled 1987 ACR criteria for RA between 1980 and 2007. The cumulative prevalence of gout in RA adjusted for the competing risk of death was estimated.

Executive summary

Background

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Gout: The Other Gene That Affects Urate Levels and Gout Development

The ABCG2 gene belongs to a group of genes called the ATP-binding cassette family; genes in this family provide instructions for making proteins that transport molecules across cell membranes. In the intestines, the ABCG2 protein helps release (secrete) a substance called urate into the urine. Urate is a byproduct of certain normal biochemical reactions in the body. In the bloodstream it acts as an antioxidant, protecting cells from the damaging effects of unstable molecules called free radicals. Urate levels are regulated by the kidneys and, to a lesser extent, by the intestines.

The ABCG2 protein also transports certain drugs out of cells. For example, this protein clears some chemotherapy drugs from organs and tissues. Transport of these drugs allows them to have their intended effects and be eliminated from the body.

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Is it OK to walk with gout?

Medical News Today: It is safe for people to walk with gout. In fact, doing joint friendly activities such as walking can help improve gout-related pain.

Gout is a form of arthritis that usually affects the big toe joint, but it can also affect the lesser toes, ankles, and knees. It normally affects one joint at a time.

People with gout may find it difficult to carry out physical activity, or they may be worried that physical activity will make their gout worse.

This article will examine whether or not it is safe to walk with gout. It will also cover how to manage, treat, and prevent this condition.

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In-hospital cardiac procedures up for those with gout, rheumatoid arthritis

(HealthDay)—Rates of in-hospital cardiac procedures continued to increase in people with gout and rheumatoid arthritis (RA) from 1998 to 2014, although they decreased for the general population, according to a study published online Feb. 25 in Therapeutic Advances in Musculoskeletal Disease.Jasvinder A. Singh, M.B.B.S., M.P.H., and John Cleveland, M.D., both from the University of Alabama at Birmingham, used data from the U.S. National Inpatient Sample (1998 to 2014) to examine the frequency of seven common cardiac and orthopedic procedures in hospitalized people with gout and RA compared to the general population.

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Inflammation and COVID-19 | Gout and Inflammation | Coronovirus | Flu

If you suffer with inflammation (Arthritis, Gout, Diabetes, etc.), are you more susceptible to viruses such as the Flu and COVID-19?

Higher levels of inflammatory markers such as C-reactive protein, ferritin, and D-dimers have been found in the blood of COVID-19 patients. Increased serum levels of several inflammatory cytokines and chemokines have been associated with the severity of the condition, as well as with the deaths involved. The way this virus invades the cells sets off a cytokine (small proteins important in cell signaling) storm, hampering the body’s ability to deal with its destructive path. The strength of the inflammatory response with this virus far exceeds what is typical for other viral infections. We are aware that hyperinflammation has been observed in younger patients without pre-existing conditions, making those with pre-existing inflammation that much more susceptible.

You may not think of Gout as a “pre-existing” condition that places you at higher risk, but it most certainly can do just that. Inflammation is still at the root of this painful disease and while your body is already struggling to keep that at bay, your risk factor is naturally higher than others. Additionally, more men seem to be suffering with extreme complications involving COVID-19, even at younger ages, much like we see with the likelihood and severity of Gout in men. Comparatively speaking, premenopausal women seem to be more protected from more severe complications of this virus vs. postmenopausal women — also another common scenario involved with Gout in women.

Uncontrolled, chronic inflammation can result in, or be the result of, a dysfunctional immune system. This can make it exceedingly difficult to keep certain pathogens in check and result in triggering an overproduction of immune cells that could flood the lungs. Widespread inflammation can negatively impact all organs of the body. When a virus replicates faster than the immune system can respond the body can quickly become overwhelmed and spiral out of control. This is where updated medical technology is needed to monitor the lungs and other organs. People can click here for info on what is needed to help keep people safe and secure during these terrifying times.

While data characterizing the immune and inflammatory status in patients with COVID-19 is in its infancy, it is obvious that inflammation contributes to the disease’s severity and risk of death. Our body’s potent immune response to COVID-19 poses unique risks to the heart, which is likely underestimated by comparison to the lung/respiratory system involvement. Systemic inflammation has been a well-known trigger for cardiovascular events, and this is no exception. As a result, anti-inflammatory treatments, such as Colchicine, are actively being researched as a potential hope for COVID-19 treatment. Researchers are also considering other therapies specific to inhibiting inflammation, such as the sex hormone progesterone.

Naturally (pun intended) our company airs on the side of alternative options to prescription anti-inflammatories. We won’t bore you with the gazillion reasons why (links on this page speak for themselves), but we will guide you towards the all-natural options for building your immunity, fighting Gout, fighting inflammation as a whole, and lowering your risk of susceptibility due to your pre-disposition.

Taking care of yourself is always important, and even more so considering this pandemic. Mental health is equally as important. Stress, anxiety and depression are very acidic and damaging to the body. Taking care of yourself emotionally needs to remain as much of a priority as doing so physically. The mind is a powerful thing, nurture it.

Uric Acid Metabolism and the Effects of Fructose

Sugar intake has risen dramatically over the last century which seems to correlate closely with the rise in obesity, diabetes, and metabolic syndrome.  Simple sugars include both glucose and fructose.  While glucose is generally utilized by the body for energy production, fructose is known to produce high amounts of harmful substances.  Added sugars to our food sources mostly stem from fructose, and fructose metabolism can cause some pretty significant damage.  Fructose can actually deplete our energy sources, cause death to our cells, stimulate fat making enzymes, and produce excess uric acid.

Studies on rats have shown fructose intake to instigate all markers of metabolic syndrome – increased waistline, obesity, diabetes, hypertension, non-alcoholic fatty liver disease, lipid abnormalities, dementia, cardiovascular disease, and cancer.    These studies have also shown high fructose intake to stimulate free radicals, weaken the arteries, create a fatty liver, and cause kidney damage. Continue reading “Uric Acid Metabolism and the Effects of Fructose”

The Benefits of Turmeric (Curcumin) – Gout, Inflammation and Disease

turmeric curcumin

TURMERIC (Curcumin)

Herbs and spices have more antioxidants than any other food group. Turmeric (Curcumin) is among these potent antioxidants. With its use, one could help prevent DNA mutations that lead to cancer and another disease. The number of cells with DNA damage could essentially be cut in half with just a little bit of this yellow magic. Many people opt to take or make supplements with this spice contained in it, which you can find more about as you explore the different vendors for these items.

A number of clinical trials have tested Curcumin (the pigment in Turmeric that yields its bright yellow color) against a number of diseases. The trials have shown this spice to play a significant role in the prevention and/or treatment of brain diseases, a variety of cancers, lung diseases, and painful joint conditions.

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Oh no! Santa has the Gout…..

How to survive the Christmas and Holiday Season if you suffer with Gout

A beacon has been sent out from the North Pole summonsing a doctor to come and see what could possibly be wrong with Santa. He can barely move his foot without pure agony. The weight of his bed cover alone is sending him through the roof in pain. Mrs. Claus is distraught. Mr. Claus is running a fever, he has the chills, and his big toe is as red and shiny as Rudolph’s nose.

The doc arrives:

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Can you repair Gout and Arthritis on your own?

All natural healing is guaranteed with patience and understanding. Having a better understanding of your condition can pave the path to lifelong success in controlling it for good.  Knowledge of your disorder, and all the contributing factors in your life having led up to your very current ailment(s), can make for a better understanding of the necessary approach and commitment to resolving it. 

Inflammatory diseases are not an overnight occurrence.  Some of you may be approaching natural healing as your first form of treatment, while many of you have suffered for years upon years, and the prescription drugs are no longer helping you.  Natural healing may not be a “quick-fix”, but it also avoids the common “band-aid” for your symptoms like many modern-day prescription drugs. Instead of treating your symptoms, natural healing aims to repair the problem that is causing your symptoms in the first place.

Do you feel like you’ve already tried everything to heal on your own, without long-term success? 


Things we hear often:

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Traditional Gout Medications

Most commonly prescribed Gout medication options include:

Xanthine Inhibitors: These actually block the enzyme, (xanthine oxidase) necessary for the conversion of purines to uric acid. As of result, blood serum levels are lowered and used to prevent chronic gout, stones, and hyperuricemia. It is not actually a treatment for an acute attack, and can even exacerbate an attack if used while it’s running its course. This treatment sounds good in theory, however, un-naturally stopping a very natural and necessary production such as uric acid must take its toll on the body somehow? After all, uric acid is a potent antioxidant vital to the human body. Attempting to halt its production could be detrimental to its important role as the protector of our DNA. As a result, it is necessary to monitor the liver, kidneys, and blood during its use.

Possible side effects include:

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