Gout and Kidney Stones

Kidney Stones

Kidney Stones (renal calculi) are formed as a result of a buildup of dissolved minerals on the inner lining of the kidneys. Once they make their way into the urinary tract severe pain in the groin, stomach, or flank area can ensue. A decrease in urination coupled with a large amount of stone-forming substances can cause these types of stones to appear. These stones can be formed by the mixture of calcium with oxalate or phosphate; and/or the combination of uric acid and amino acid cysteine.

Much like Gout, Kidney stones are being diagnosed more and more in recent years. The same type of stones can develop in the bladder as well, but are much more uncommon and have remained relatively low and unchanged by comparison. Over the span of almost 30 years, the Mayo Clinic observed a significant rise in the incidences of kidney stones; particularly in adult women. With more accurate CT scans our ability to monitor and diagnose stones are partly behind a good portion of this rise in cases, but also goes hand in hand with the rise in Obesity and Diabetes Type 2. Diets high in sugar, unhealthy fats, and salt have been to blame for stones and this type of diet certainly fits the profile for all of these conditions.

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Gout and Cancer Connection?

Gout and Cancer Connection?

Is there a connection between Gout and Cancer?  Gout is a common inflammatory disease with incidences largely increasing with each passing year and affecting younger and younger age groups  more than ever before.  Acute arthritis and hyperuricemia stems from purine metabolism dysfunction, causing urate crystals to deposit into the tissue leading to kidney stones, soft tissue growths, urate nephropathy and/or arthritis.  Epidemiological studies have been conducted to estimate the potential association between Gout and Cancer risks.  These studies have displayed a preeminent role of Gout in carcinogenesis.

Cellular death and higher turnover rates can bring about hyperuricemia and the formation of tumors (tumorigenesis.)  Even though strong evidence exists to show the connection between high serum uric acid levels and an independent increased risk of cancer, the subject remains disputable. Continue reading “Gout and Cancer Connection?”

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