What is TAK1 and why is it important to inhibit its potentially destructive pathway?

TAK1 is an enzyme and signaling molecule in humans encoded by the MAP3K7 gene (a mitogen-activated protein).  TAK1 regulates cellular death through various pathways.  As we have discussed before, programmed cell death is a normal, physiologic process intended to help remove damaged cells.  However, unattended cell death is the direct pathway for human disease.  TAK1 contains binding proteins that are responsible for cell viability and tissue balance in a variety of organs. 

TAK1 is a key molecular component that can readily determine of the fate of our body’s cells.  TAK1 has been typically considered pro-survival, however, recent studies have determined that various factors could cause it to induce cell death.  Scientifically speaking, studies are exploring the ability to inhibit TAK1 as a therapeutic approach to killing off rogue cancer cells and stopping chronic inflammatory response.

Continue reading “What is TAK1 and why is it important to inhibit its potentially destructive pathway?”

Candidiasis: Yeast overgrowth and Gout

Candida yeast overgrowth in the body can contribute to difficulty with weight loss, inflammation, increased uric acid levels, and a host of other symptoms. In fact, the symptoms of chronic inflammation are extraordinarily similar to those seen in Candida related complex. Digestive problems, allergies, fatigue, and joint pain are no strangers to either condition. We have a bad habit of evaluating conditions separately, when in fact the powerful links between Gout and Candida yeast overgrowth could be addressed collectively.


Harmful substances that enter the bloodstream can cause a host of problems. The byproducts of Candida (acetaldehyde, ammonia, and uric acid) are no exception. Our bodies have a remarkable way of dealing with these invaders that can be both helpful and harmful. Inflammatory response is the key component for your body’s way of healing itself in the presence an injury, an infection, or in this case when dangerous pathogens are invading your system.


Many relate candida yeast solely to women and the vagina infections the yeast can cause. However, yeast can be found in the mouth, intestines, and on the skin. When it begins to grow uncontrollably it can cause an infection known as candidiasis.
We rely on the healthy bacteria levels in our body to keep Candida levels in check. However, in the presence of low “good bacteria” levels (quite common) the immune system becomes compromised and the overproduction of both yeast and Uric Acid can ensue.
Much like uric acid, candida faces similar risk factors that can lead to its overproduction such as:

Antibiotic use
A diet high in sugar and refined carbs
Excessive alcohol intake
Compromised immune system
Prescription medications
Diabetes
Stress

Continue reading “Candidiasis: Yeast overgrowth and Gout”

Uric Acid in the Joints

Soluble uric acid can be measured in your blood supply. However, the uric acid that has crystallized and is now residing in connective tissue cannot be measured with a blood analysis. These crystals are always there, in a solid form, “melting” when the levels in the blood will allow, and adding to the build up when levels in the blood become too high for the blood to carry. These deposits are what migrate into the joint causing the acute gout attack. When the tissue is full, any food indulgences and lifestyle choices that cause you to produce more uric acid than the blood can hold, will allow for deposits that crystallize between the bone joints. This can make you falsely blame one food for triggering your attack when in all actuality it simply “tipped the already full cup over.”

Continue reading “Uric Acid in the Joints”

Are you doing enough to avoid the Coronavirus AND Gout Attacks?

Can this virus raise your threat of a Gout attack?

Can illness increase your arthritic joint pain and inflammation, in general?

As the coronavirus spreads it is important not only to reduce your exposure, but also to boost your immunity should exposure become your reality. We have always preached the necessity to enhance your immune system in order to fight chronic inflammation and Gout, and now it’s more important than ever! Some tweaks to our diet, water intake, supplement selections, our actions and our thought patterns, can make this all possible.

Optimizing your health through diet, water, sleep, and supplementation won’t only enhance your health overall, it will enhance your body’s ability to ward or fight off any of those nasty germs surrounding you. Even if you succumb to the germs, you can drastically reduce the severity of the hit with a strengthened immune system. Whilst you’re keeping your immune system up, don’t forget to visit a website to buy a face covering of some sort to protect you when you’re out and about. Local shops will also be selling face masks if you cannot access any online.

Sleep might just be at the top of the most underrated list. Lack of sleep can really weigh on your immune system making you susceptible to environmental influences such as colds and flu viruses. Please aim for a solid 8 hours, without medication if possible. Sleep drugs pretty much defeat the purpose and only add to the body’s acidity, causing more trouble in the long run. Continue reading “Are you doing enough to avoid the Coronavirus AND Gout Attacks?”

New Year’s Resolution – Gout Free in the New Year

What is the number one reason that New Year’s resolutions fail?

Most people know what they want, but they don’t fully understand how to actually achieve their goal. Most resolutions require a decent amount of patience and understanding, and whole lot of effort. We cannot treat a marathon like a sprint; bad habits don’t die easily.
You must approach this goal with the understanding that Gout did not take place overnight, and neither will your healing. So many people fail at achieving their goals because they are in too much of a hurry and desire immediate satisfaction. When it comes to Gout pain, it is easily understood why we resort to quick-fix prescription medications even though we know they aren’t really “fixing” anything. We need immediate pain relief, and rightfully so. However, you can still begin the true healing process and we can show you the way.

Having a New Year’s Resolution for Joint health and Gout Control is a great idea. You may know what you want, but not how to go about achieving this goal – BUT WE DO!

A few life-changing Louise Hay Affirmations by Jennifer Williamson – You CAN Heal Your Life:

Continue reading “New Year’s Resolution – Gout Free in the New Year”

What is Refractory Gout?

Gout is the most common form of chronic, progressive, inflammatory arthritis. Its prevalence continues to increase worldwide. This condition seems to baffle several fields of medicine who deal with patients suffering with the relentless disease, including podiatrists, chiropractors, rheumatologists, and general practitioners alike.


The deposits of MSU, monosodium urate, crystals into the synovial fluid and other tissues take place when the serum uric acid concentration exceeds its solubility. As this progresses, these deposits can occur just about anywhere in the body and lead to chronic pain, bone erosions, tophi, and general joint deformities. This condition can become downright debilitating, and rather difficult to treat. Continue reading “What is Refractory Gout?”

error

Enjoy this blog? Please spread the word :)