Incident gout and risk of first-time acute coronary syndrome: a prospective, population-based, cohort study in Sweden
Panagiota Drivelegka MD, PhD,Lennart T.H. Jacobsson MD,Ulf Lindström MD,Karin Bengtsson MD, PhD,Mats Dehlin MD
First published: 12 September 2022
To investigate the risk of first-time acute coronary syndrome (ACS) in a large cohort of primary and secondary care patients with incident gout, compared to the general population.
Continue reading “Gout Comes With Increased Heart Risk”
Cardiovascular Disease and Gout
The prevalence of cardiovascular disease continues to rise and is among the leading cause of mortality in the world. Inflammatory conditions such as Rheumatoid Arthritis and Gout are often associated with a higher risk and earlier onset of this disease. Research links gout to an increased risk of several types of cardiovascular disease, including heart attack, heart failure, and atrial fibrillation, or an irregular heartbeat. Epidemiological, experimental, and clinical data show that patients with hyperuricemia SUA are at increased risk of cardiac, renal, and vascular damage and CV events. Continue reading “Does Gout Increase The Cardiovascular Disease Risk Factor?”
Inflammation is a natural, thriving mechanism of the immune system. Acute inflammatory response is a way to fire at and ward off disease and infection, as well as to fuel cellular regeneration. We all require a healthy measure of inflammation in order to survive. What happens when the body feels as though it is constantly under an attack of some sort? What if the inflammatory response persists and you are plagued with an incessant slow burning fire inside of you? This is precisely when a good thing, goes bad.
The body is amazingly resilient, but relies solely upon communication between the major systems within the body (the endocrine, digestive, respiratory/cardiovascular, and the central nervous system) in order to function and heal properly. When chronic inflammation is present, these systems can no longer communicate, and disease is
Continue reading “INFLAMMATION: WHEN A GOOD THING GOES BAD”
According to the latest CARES trial, the Gout drug Febuxostat (Uloric) failed up against Allopurinol when it came down to a combined rate of fatal and nonfatal adverse events for those that suffer with both Gout and Cardiovascular disease. In fact, there was a significant increased risk of death for those that took this drug for Gout while also suffering from heart disease.
The trial was mandated by the FDA and consisted of 6,190 patients, 84% of which were men. Cardiovascular risk is naturally increased in patients with Gout. The study was attempting to look at any difference in outcome for these patients taking Febuxostat, a nonpurine xanthine oxidase inhibitor, or those taking Allopurinol, a purine base analogue xanthine oxidase inhibitor. The patients were followed for a median of 32 months, and a maximum of 85 months. Without diving into all of the ratio statistics, the all-cause and cardiovascular mortality rate was higher in the Febuxostat group, 34% and 22% higher respectively. Continue reading “New evidence of increased risk of death with Febuxostat (Uloric)”
Regular physical activity can offer us a multitude of health benefits. Recent studies show just 20 minutes a day can produce anti-inflammatory effects, adding to the already lengthy list of how fitness can support our bodies. That’s right! In addition to reducing heart disease, lowering blood pressure, reducing the risk of Diabetes type 2, reducing the risk of cancer, improving metabolism and weight loss, strengthening the heart, muscles, and bones — regular exercise can also reduce inflammation and your chances of suffering from other inflammatory conditions.
Twenty minutes a day is all it takes. Researchers believe that Continue reading “Does Exercise Help Reduce Inflammation?”
Gout affects an estimated 4% of the population, or around 1 in 25 people. Evidence suggests this number is growing and is certainly affecting a larger demographic than in the past. A lot of confusion has surrounded the specifics on how high levels of uric acid may affect the heart and kidneys, even when acute Gout attacks are not present.
There have been studies attempting to separate the mortality rates of those with other risk factors, namely cardiovascular disease and diabetes, from those with just Gout and/or high uric acid levels. The findings seem to suggest that Gout and high uric acid levels are independently responsible for higher death rates across most age, sex, and race subgroups independent of other pre-existing conditions. The University in Limerick found those with the high serum uric acid levels displayed at 77% higher risk of death from all causes, and a 209% higher risk of cardiovascular death. While pre-existing conditions such as obesity, hypertension, diabetes, etc. are strongly associated with a higher death risk, the results did not decrease by much when those factors were removed.
What does this mean for the Gout sufferer? Continue reading “Gout, uric acid, and risk of death”
We all know that stress can cause ailments such as difficulty sleeping, muscle tension, changes in appetite, headaches, stomach problems, panic attacks, and prolonged feeling of sadness or worthlessness. But, did you also know that stress can literally alter the cells in our body and lead to chronic inflammation and serious diseases? Prolonged, overexposure to cortisol and other stress hormones can wreak havoc on the mind and body. That is why people want to turn to more natural/herbal remedies in helping them lower their cortisol levels. From taking herbal tablets, to trying weed and looking up how to pack a glass blunt, there is a myriad of ways people can reduce stress levels naturally.Chronic stress can reprogram the cells in our body and disrupt all of it’s processes.
A region at the base of our brain, the hypothalamus, is set off in the presence of a perceived threat. In turn, this signals the pituitary and adrenal glands to release a surge of hormones, including adrenaline and cortisol. Cortisol is the main hormone responsible for Continue reading “Chronic Stress, Chronic Inflammation, and Disease”