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Gut Health and Uric Acid Connection

Gut health plays an important role in controlling gout, primarily because it influences how your body processes and excretes uric acid, which is the substance responsible for gout. Gout is a form of arthritis that occurs when uric acid builds up in the bloodstream and forms crystals in the joints, causing painful inflammation. The connection between gut health and gout is multi-faceted, involving digestion, inflammation, and even the balance of gut microbiota.

Here’s how gut health can influence gout control:

Is there a Global Gout Burden? Check out the latest study…..

According to a study published in The Lancet Rheumatology, gout cases are projected to increase by over 70% by 2050. This underscores the urgent need for effective management and prevention strategies.

To address both current and future demands, it is essential to analyze the burden of gout by age and sex and make future projections. Researchers used data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) covering 1990 to 2020 to evaluate global, regional, and national prevalence trends and to predict future prevalence up to 2050.

Inflammation and Hydration: What is the connection?

Inflammation and hydration are interconnected aspects of health, and understanding their relationship can be crucial for managing various health conditions and maintaining overall well-being.

Inflammation

Inflammation is a natural and essential part of the body’s immune response. It helps the body to fight off infections, injuries, and toxins, and it plays a role in healing. There are two types of inflammation:

Occurrence of Gout in Rheumatoid Arthritis: It Does Happen!

A Population-Based Study

International Journal of Clinical Rheumatology

Adlene J Jebakumar; Prabhu D Udayakumar; Cynthia S Crowson; Eric L Matteson

Int J Clin Rheumatol. 2013;8(4):433-437

Discussion

The co-occurrence of gout and RA is rarely reported. In addition to the widespread belief that gout and RA do not, or rarely, coexist in the same patient, it can be difficult to clinically differentiate RA from polyarticular tophaceous gout especially when gout involves the hands. Only 33 cases with coexisting RA and gout have been reported in the English literature prior to this study. These include a report of eight cases of coexisting RA and gout between 1994 and 2005 at Chang Gung Memorial Hospital (Taiwan); this report also included the features of 24 previously reported similar cases in the English literature.^[8] A further case with coexisting chronic gout and RA was reported in 2007.^[9] Of these 33 previously reported cases, 23 had gout preceding the diagnosis of RA, whereas in our study, only six out of 22 patients had a diagnosis of gout prior to incidence of RA.^[8,9] All the previously reported cases of coexisting gout and RA had microscopic evidence of monosodium urate crystals in the synovial fluid or tophus. Rheumatoid factor was present in 24 out of the 33 previously reported cases compared with 14 out of 22 cases in our study. There was predominance of males, with 23 out of the 33 previously reported cases affecting men similar to our findings.^[8,9]

High Waist Circumference and Increased Lipid Levels Predictive of Unfavorable Gout Outcomes Over 2 Years

Hibah Khaja, PharmD | January 17, 2024

Anthropometric measures remained stable over a 2-year period among patients actively treated for gout, while lipid levels showed a decrease. After 2 years, high waist circumference and lipid levels were associated with unfavorable gout outcomes.

Anthropometric measures remained stable over a 2-year period among patients actively treated for gout, while lipid levels showed a decrease. After 2 years, high waist circumference (WC) and lipid levels were associated with unfavorable gout outcomes, according to study results published in Rheumatic & Musculoskeletal Diseases Open.

Experts on how water intake affects uric acid levels in the body

Story by Lifestyle Desk

Here’s what to know about uric acid levels and kidney function:

A less commonly spoken health risk among those associated with lack of adequate water intake is less uric acid levels in the body. Notably, while uric acid is a waste product, produced during the breakdown of various foods and drinks, its production too affects your health.

“Normally, uric acid dissolves in the blood and is discarded by the kidneys through urine. But in some cases, the body produces excess uric acid or the kidney dysfunction doesn’t excrete the required amount of uric acid, resulting in hyperuricemia. Long-term hyperuricemia can lead to development of gout, a painful form of arthritis, or kidney stones,” Dr Avanish Arora, director – Urology and Uro-Oncology & Senior Consultant – Robotic Urology, Nanavati Max Super Specialty Hospital, Mumbai told indianexpress.com.

Fried Food Causes Inflammation & Weight Gain

Inflammation is a hot topic for weight loss and wellness—and for good reason. Research shows that chronic, low-grade inflammation can result in many major health issues, including heart disease, cancer, Type 2 diabetes, and more. If you suffer from chronic inflammation, you know how annoying it can be. From discomfort and digestive issues to fatigue and weight gain, inflammation is the worst. And, while most advice seems to focus on the best anti-inflammatory foods, it’s just as important to reduce foods that may be triggering or aggravating your condition. One of the biggest food group offenders for inflammation is fried foods.

Study discovers T cells in human blood secrete a substance that affects blood pressure and inflammation

Acetylcholine regulates blood flow, but the source of blood acetylcholine has been unclear. Now, researchers at Karolinska Institutet have discovered that certain T cells in human blood can produce acetylcholine, which may help regulate blood pressure and inflammation. The study, which is published in PNAS, also demonstrates a possible association between these immune cells in seriously ill patients and the risk of death.

Two blood pressure drugs may cause sharp crystals to fuse in the joints – gout attack risk

Treatment with the two drugs could spell trouble for individuals at risk of arthritis, research suggests.

By SOLEN LE NET

Arthritis describes a broad range of inflammatory diseases, some of which are more painful than others. In gout, a surplus of uric acid in the body coalesces into sharp crystals that build up and spur inflammation in the joints. Pain and swelling are common symptoms, but as attacks intensify the condition can become increasingly debilitating.

Binge-eating and lack of exercise during lockdown has triggered huge increase in gout, data suggests

Hospital admissions for gout have surged due to binge-eating during lockdowns
Gout is a type of inflammatory arthritis that causes sudden and severe joint pain
The joint pain is usually in your big toe but can also be found in other joints

By XANTHA LEATHAM HEALTH AND SCIENCE REPORTER FOR THE DAILY MAIL

PUBLISHED: 17:22 EST, 14 August 2022 | UPDATED: 17:22 EST, 14 August 2022

Tag: gout