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Important tips regarding Gout and other Inflammatory Conditions

Eating too much causes inflammation-

We know that overeating promotes the inflammatory response and suppresses the immune system. Tests performed by the National Institute on Aging revealed that when animals were fed 50 percent fewer calories per day, their immune response improved, the number of inflammatory cytokines in circulation was reduced, thymus size was maintained and inflammation-fighting T-cell function improved. This study looked at higher and lower calorie consumption; it did not distinguish among the types of calories consumed. Heavy, red-meat-based diets or lots of sugar-laden foods would definitely have a negative impact on immune function and promote inflammation, whereas calories in the form of fruits, vegetables, legumes, nuts and seeds would improve immunity. No matter what the food choices, moderation is the key in terms of both total daily quantity and amounts consumed at one time. Generally, five or six small meals (of the right foods) throughout the day are considered to be healthier than consuming fewer large ones. [4]

Traditional Gout Medications

Most commonly prescribed Gout medication options include:

Xanthine Inhibitors: These actually block the enzyme, (xanthine oxidase) necessary for the conversion of purines to uric acid. As of result, blood serum levels are lowered and used to prevent chronic gout, stones, and hyperuricemia. It is not actually a treatment for an acute attack, and can even exacerbate an attack if used while it’s running its course. This treatment sounds good in theory, however, un-naturally stopping a very natural and necessary production such as uric acid must take its toll on the body somehow? After all, uric acid is a potent antioxidant vital to the human body. Attempting to halt its production could be detrimental to its important role as the protector of our DNA. As a result, it is necessary to monitor the liver, kidneys, and blood during its use.

Possible side effects include:

INFLAMMATION: WHEN A GOOD THING GOES BAD

Inflammation is a natural, thriving mechanism of the immune system. Acute inflammatory response is a way to fire at and ward off disease and infection, as well as to fuel cellular regeneration. We all require a healthy measure of inflammation in order to survive. What happens when the body feels as though it is constantly under an attack of some sort? What if the inflammatory response persists and you are plagued with an incessant slow burning fire inside of you? This is precisely when a good thing, goes bad.

The body is amazingly resilient, but relies solely upon communication between the major systems within the body (the endocrine, digestive, respiratory/cardiovascular, and the central nervous system) in order to function and heal properly. When chronic inflammation is present, these systems can no longer communicate, and disease is

Continue reading “INFLAMMATION: WHEN A GOOD THING GOES BAD”

Gout and Kidney Stones

Kidney Stones

Kidney Stones (renal calculi) are formed as a result of a buildup of dissolved minerals on the inner lining of the kidneys. Once they make their way into the urinary tract severe pain in the groin, stomach, or flank area can ensue. A decrease in urination coupled with a large amount of stone-forming substances can cause these types of stones to appear. These stones can be formed by the mixture of calcium with oxalate or phosphate; and/or the combination of uric acid and amino acid cysteine.

Much like Gout, Kidney stones are being diagnosed more and more in recent years. The same type of stones can develop in the bladder as well, but are much more uncommon and have remained relatively low and unchanged by comparison. Over the span of almost 30 years, the Mayo Clinic observed a significant rise in the incidences of kidney stones; particularly in adult women. With more accurate CT scans our ability to monitor and diagnose stones are partly behind a good portion of this rise in cases, but also goes hand in hand with the rise in Obesity and Diabetes Type 2. Diets high in sugar, unhealthy fats, and salt have been to blame for stones and this type of diet certainly fits the profile for all of these conditions.

Understanding Uric Acid

Uric Acid

Purines perform multiple important functions within our cells, including regulating energy metabolism and signaling the energy conversion from one to another. Purines are essentially the building blocks for all living things as a necessity for the growth, proliferation and survival of all cells. The two purine bases, adenine and guanine, create bonds that form the DNA ladder. Humans breakdown purines and convert them into uric acid.

Uric acid happens to be a potent DNA protector. All other mammals possess an enzyme known as uricase. Uricase converts uric acid into allantoin, which can easily travel through the bloodstream and readily eliminated through the urine. Humans do not possess this enzyme, therefore, we cannot oxidize uric acid into the more soluble compound of allantoin. Our liver and kidneys are left to do the all-important jobs of purine breakdown and uric acid disposal, conducted respectively.

Fructose and Uric Acid Metabolism

Sugar intake has risen dramatically over the last century which seems to correlate closely with the rise in obesity, diabetes, and metabolic syndrome. Simple sugars include both glucose and fructose. While glucose is generally utilized by the body for energy production, fructose is known to produce high amounts of harmful substances. Added sugars to our food sources mostly stem from fructose, and fructose metabolism can cause some pretty significant damage. Fructose can actually deplete our energy sources, cause death to our cells, stimulate fat making enzymes, and produce excess uric acid.

Studies on rats have shown fructose intake to instigate all markers of metabolic syndrome – increased waistline, obesity, diabetes, hypertension, non-alcoholic fatty liver disease, lipid abnormalities, dementia, cardiovascular disease, and cancer. These studies have also shown high fructose intake to stimulate free radicals, weaken the arteries, create a fatty liver, and cause kidney damage. Continue reading “Fructose and Uric Acid Metabolism”

How to travel and avoid Gout

Traveling can be hectic as is, and downright scary if you suffer from Gout. If you are going abroad it can be even more of a worry as you are not near home, or in the same country to get the help you need, that is why making a packing list, or checking one out from such websites as Rent.is can be very beneficial. Why does Gout tend to attack at THE worst imaginable times and can you avoid this fate?

The anticipation and fear of the next Gout attack can be extremely stressful. Travel can be very stressful, too. Unfortunately, stress can actually CAUSE an attack. Stress can dramatically alter the pH of the body increasing its acid load, pulling minerals from the body, and triggering inflammation. While finally arriving at your destination can be relaxing and fun, the stress leading up to that point could cause problems.

· Try to pack well ahead of time and don’t overthink it. Most people don’t use half of the things they bring. Make a list over a long period of time and stick to it.

· If you are flying, have your documents for security set aside separately and plan to arrive with plenty of time to spare.

· Get plenty of rest, stay hydrated, and eat well (at least leading up to the vacay.)

· Stress and travel can deplete the healthy bacteria in the body. Taking a high quality probiotic before, during, and after travel can help a great deal.

· Breathe deeply and try to relax. Continue reading “How to travel and avoid Gout”

Gout, uric acid, and risk of death

Gout affects an estimated 4% of the population, or around 1 in 25 people. Evidence suggests this number is growing and is certainly affecting a larger demographic than in the past. A lot of confusion has surrounded the specifics on how high levels of uric acid may affect the heart and kidneys, even when acute Gout attacks are not present.

There have been studies attempting to separate the mortality rates of those with other risk factors, namely cardiovascular disease and diabetes, from those with just Gout and/or high uric acid levels. The findings seem to suggest that Gout and high uric acid levels are independently responsible for higher death rates across most age, sex, and race subgroups independent of other pre-existing conditions. The University in Limerick found those with the high serum uric acid levels displayed at 77% higher risk of death from all causes, and a 209% higher risk of cardiovascular death. While pre-existing conditions such as obesity, hypertension, diabetes, etc. are strongly associated with a higher death risk, the results did not decrease by much when those factors were removed.

What does this mean for the Gout sufferer? Continue reading “Gout, uric acid, and risk of death”

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