uric acid

Gout and Kidney Disease

Chronic kidney disease (CKD)

Chronic kidney disease (CKD) limits the amount of waste filtration your body is capable of processing. Uric acid is not seen as a foreign matter to the body, therefore is usually last to be dealt with from a toxin filtering standpoint. This can allow for uric acid build-up, and, in turn, the increased likelihood of developing Gout. The medications used to treat kidney disease have also been associated with drug-induced cases of Gout. Diuretics and beta blockers are typically used for kidney disease induced high blood pressure and are well known to contribute to Gout development.

There is enough scientific research to confirm that kidney disease can cause Gout. How about the opposite? Can Gout lead to kidney disease? The chicken or the egg? Uric acid is filtered through the kidneys, an undeniable relation to both diseases. While this connection may be less established, the evidence is certainly present. Each condition is well-equipped to feed the other.

Traditional Gout Medications

Most commonly prescribed Gout medication options include:

Xanthine Inhibitors: These actually block the enzyme, (xanthine oxidase) necessary for the conversion of purines to uric acid. As of result, blood serum levels are lowered and used to prevent chronic gout, stones, and hyperuricemia. It is not actually a treatment for an acute attack, and can even exacerbate an attack if used while it’s running its course. This treatment sounds good in theory, however, un-naturally stopping a very natural and necessary production such as uric acid must take its toll on the body somehow? After all, uric acid is a potent antioxidant vital to the human body. Attempting to halt its production could be detrimental to its important role as the protector of our DNA. As a result, it is necessary to monitor the liver, kidneys, and blood during its use.

Possible side effects include:

Understanding Uric Acid

Purines perform multiple important functions within our cells, including regulating energy metabolism and signaling the energy conversion from one to another. Purines are essentially the building blocks for all living things as a necessity for the growth, proliferation and survival of all cells. The two purine bases, adenine and guanine, create bonds that form the DNA ladder. Humans breakdown purines and convert them into uric acid.

Uric acid happens to be a potent DNA protector. All other mammals possess an enzyme known as uricase. Uricase converts uric acid into allantoin, which can easily travel through the bloodstream and readily eliminated through the urine. Humans do not possess this enzyme, therefore, we cannot oxidize uric acid into the more soluble compound of allantoin. Our liver and kidneys are left to do the all-important jobs of purine breakdown and uric acid disposal, conducted respectively.

Gout and Cancer Connection?

Is there a connection between Gout and Cancer? Gout is a common inflammatory disease with incidences largely increasing with each passing year and affecting younger and younger age groups more than ever before. Acute arthritis and hyperuricemia stems from purine metabolism dysfunction, causing urate crystals to deposit into the tissue leading to kidney stones, soft tissue growths, urate nephropathy and/or arthritis. Epidemiological studies have been conducted to estimate the potential association between Gout and Cancer risks. These studies have displayed a preeminent role of Gout in carcinogenesis.

Cellular death and higher turnover rates can bring about hyperuricemia and the formation of tumors (tumorigenesis.) Even though strong evidence exists to show the connection between high serum uric acid levels and an independent increased risk of cancer, the subject remains disputable. Continue reading “Gout and Cancer Connection?”

Gout can be found in dogs and other animals

Excessive amounts of uric acid in the bloodstream are not limited to only humans. Gout can affect our loving canine and feline friends, as well. Whereas humans are more likely to experience crystal deposits in the joint extremities, animals tend to grow uric acid crystals in their urine. When animals are unable to assimilate calcium and other minerals, abnormal uric acid and calcium levels can also deposit into the paws, toes, elbows, neck, ears, and tongue. This is know as calcified skin lesions, or Casinosis Cutis, and more common in breeds such as Boxers and Boston Terriers. Calcium “Gout” can also create a chalky liquid that can ooze from the paws. Continue reading “Gout can be found in dogs and other animals”

Gout, uric acid, and risk of death

Gout affects an estimated 4% of the population, or around 1 in 25 people. Evidence suggests this number is growing and is certainly affecting a larger demographic than in the past. A lot of confusion has surrounded the specifics on how high levels of uric acid may affect the heart and kidneys, even when acute Gout attacks are not present.

There have been studies attempting to separate the mortality rates of those with other risk factors, namely cardiovascular disease and diabetes, from those with just Gout and/or high uric acid levels. The findings seem to suggest that Gout and high uric acid levels are independently responsible for higher death rates across most age, sex, and race subgroups independent of other pre-existing conditions. The University in Limerick found those with the high serum uric acid levels displayed at 77% higher risk of death from all causes, and a 209% higher risk of cardiovascular death. While pre-existing conditions such as obesity, hypertension, diabetes, etc. are strongly associated with a higher death risk, the results did not decrease by much when those factors were removed.

What does this mean for the Gout sufferer? Continue reading “Gout, uric acid, and risk of death”

Arthritis and Gout are no longer considered “old man diseases”……..and they are dangerous!

These painful joint conditions were once considered the inevitable outcome of old aging joints. However, these painful conditions have more than doubled in the past 10-15 years, with a shocking amount of sufferers now found to be under the age of 40. Doctors have seen the sharpest rise in patients in their 20’s and 30’s, some 30% since 2012, suffering from a disease that was once thought to be limited to royalty. Not so coincidentally, the rise in obesity, Diabetes Type 2, and prescriptions such as low-dose aspirin and diuretics has occurred almost simultaneously.

Even still there is large percentage of the population that suffers silently having never been diagnosed, or sometimes misdiagnosed. Gout especially can be overlooked by medical professionals due to inaccurate blood measurements of Uric Acid. Unless the fluid is directly aspirated from the joint it can be difficult to identify. Many that are under an attack at the time they are seen by a physician will have low to normal blood serum Uric Acid levels. Why is this? Continue reading “Arthritis and Gout are no longer considered “old man diseases”……..and they are dangerous!”

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